John Isner and Jack Sock defeated Santiago González and Édouard Roger-Vasselin in the final, 7–6^(7–4), 6–3, to win the men's doubles tennis title at the 2022 Indian Wells Masters.^[1] The victory earned Isner his second doubles title at Indian Wells, Sock his third, and the pair's second together overall at the tournament.

John Peers and Filip Polášek were the defending champions,^[2] but lost to Marcelo Arévalo and Jean-Julien Rojer in the first round.

Mate Pavić and Joe Salisbury were in contention for the world no. 1 doubles ranking at the beginning of the tournament. Pavić retained the top ranking, despite losing in the first round, after Salisbury lost in the semifinals.

	Semifinals							Final
	WC	John Isner Jack Sock	6	6
		Andrey Golubev Alexander Zverev	3	2
								WC	John Isner Jack Sock	77	6
								PR	Santiago González Édouard Roger-Vasselin	64	3
	PR	Santiago González Édouard Roger-Vasselin	3	6	[10]
	2	Rajeev Ram Joe Salisbury	6	4	[7]

	First round							Second round							Quarterfinals							Semifinals
	1	N Mektić M Pavić	62	6	[7]
	WC	J Isner J Sock	77	3	[10]			WC	J Isner J Sock	6	77
		I Dodig M Melo	5	6	[2]			WC	T Kokkinakis N Kyrgios	3	63
	WC	T Kokkinakis N Kyrgios	7	1	[10]										WC	J Isner J Sock	7	6
		R Klaasen B McLachlan	65	4											WC	F López S Tsitsipas	5	4
	WC	F López S Tsitsipas	77	6				WC	F López S Tsitsipas	6	6
		H Hurkacz Ł Kubot	2	2				6	T Pütz M Venus	4	3
	6	T Pütz M Venus	6	6																		WC	J Isner J Sock	6	6
	4	JS Cabal R Farah	710	6																			A Golubev A Zverev	3	2
		S Korda J Sinner	68	2				4	JS Cabal R Farah	1	4
		C Alcaraz P Carreño Busta	3	77	[7]				T Fritz T Paul	6	6
		T Fritz T Paul	6	65	[10]											T Fritz T Paul	4	63
		A Golubev A Zverev	7	6												A Golubev A Zverev	6	77
		D Evans K Khachanov	5	3					A Golubev A Zverev	77	6
		M Arévalo J-J Rojer	3	6	[11]				M Arévalo J-J Rojer	60	3
	5	J Peers F Polášek	6	2	[9]

	First round							Second round							Quarterfinals							Semifinals
	8	J Murray B Soares	64	4
		R Bopanna D Shapovalov	77	6					R Bopanna D Shapovalov	4	6	[4]
	PR	S González É Roger-Vasselin	77	6				PR	S González É Roger-Vasselin	6	4	[10]
		S Gillé M Middelkoop	64	1											PR	S González É Roger-Vasselin	6	6
		A Karatsev A Rublev	64	78	[10]											A Karatsev A Rublev	2	4
		R Bautista Agut A Davidovich Fokina	77	66	[5]				A Karatsev A Rublev	77	4	[10]
		N Mahut F Martin	4	4				3	M Granollers H Zeballos	62	6	[4]
	3	M Granollers H Zeballos	6	6																		PR	S González É Roger-Vasselin	3	6	[10]
	7	W Koolhof N Skupski	6	6																		2	R Ram J Salisbury	6	4	[7]
		S Bolelli F Fognini	4	4				7	W Koolhof N Skupski	6	77
		A Behar G Escobar	1	3					F Delbonis C Norrie	3	61
		F Delbonis C Norrie	6	6											7	W Koolhof N Skupski	64	5
		A Molteni D Schwartzman	6	7											2	R Ram J Salisbury	77	7
		T Brkić N Ćaćić	3	5					A Molteni D Schwartzman	3	62
		K Krawietz A Mies	62	4				2	R Ram J Salisbury	6	77
	2	R Ram J Salisbury	77	6

The following are the seeded teams, based on ATP rankings as of March 7, 2022.

Country	Player	Country	Player	Rank	Seed
CRO	Nikola Mektić	CRO	Mate Pavić	3	1
USA	Rajeev Ram	GBR	Joe Salisbury	7	2
ESP	Marcel Granollers	ARG	Horacio Zeballos	11	3
COL	Juan Sebastián Cabal	COL	Robert Farah	18	4
AUS	John Peers	SVK	Filip Polášek	24	5
GER	Tim Pütz	NZL	Michael Venus	26	6
NED	Wesley Koolhof	GBR	Neal Skupski	33	7
GBR	Jamie Murray	BRA	Bruno Soares	38	8

• Santiago González / Édouard Roger-Vasselin

• Simone Bolelli / Máximo González → replaced by Simone Bolelli / Fabio Fognini
• Dan Evans / Cristian Garín → replaced by Dan Evans / Karen Khachanov
• Sander Gillé / Joran Vliegen → replaced by Sander Gillé / Matwé Middelkoop

• Main draw