The 2010 Tour de San Luis was a men's road cycling race held from 18 to January 24, 2010, in Argentina. The fourth edition of this road racing event was a multiple stage race with seven stages and a total length of 1018.4 kilometres.
Stage summary
| Stage | Date | Start | Finish | Distance | Stage Top 3 |
|---|---|---|---|---|---|
| 1 | 18 January | San Luis | Villa Mercedes | 168.4 km |  Francesco Chicchi (ITA)  Edgardo Simón (ARG) Danilo Napolitano (ITA)
|
| 2 | 19 January | Potrero de los Funes | Mirador El Potrero | 157 km |  Rafael Valls (ESP)  Arnols Alcolea (CUB)  Jackson Rodríguez (VEN)
|
| 3 | 20 January | Fraga | Buena Esperanza | 199.7 km | Alberto Loddo (ITA) Danilo Napolitano (ITA) Francesco Chicchi (ITA)
|
| 4 | 21 January | San Luis | San Luis | 19.8 km | Vincenzo Nibali (ITA)  Robert Bengsch (GER)  Alexander Kolobnev (RUS)
|
| 5 | 22 January | San Luis | La Carolina | 156.4 km | Jackson Rodríguez (VEN) Rafael Valls (ESP)  Pedro Nicasio (BRA)
|
| 6 | 23 January | Quines | Mirador del Sol | 150 km | Luis Mate (ESP)  José Serpa (COL) Vincenzo Nibali (ITA)
|
| 7 | 24 January | San Luis | San Luis | 167.1 km | Alberto Loddo (ITA) Danilo Napolitano (ITA) Francisco Pacheco (ESP)
|