The 2010 Due Ponti Cup was a professional tennis tournament played on outdoor red clay courts. It was part of the 2010 ATP Challenger Tour. It took place in Rome, Italy between 31 May and 6 June 2010.

Nationality	Player	Ranking*	Seeding
BRA	Ricardo Mello	90	1
ITA	Paolo Lorenzi	95	2
ITA	Filippo Volandri	118	3
BRA	João Souza	125	4
ITA	Simone Bolelli	126	5
ARG	Máximo González	148	6
ROU	Victor Crivoi	158	7
ROU	Adrian Ungur	166	8

• Rankings are as of May 24, 2010.

The following players received wildcards into the singles main draw:

• Francesco Aldi
• Marco Crugnola
• Thomas Fabbiano
• Santiago González

The following players received entry into the singles main draw as an alternate:

• Martín Alund

The following players received entry from the qualifying draw:

• Facundo Bagnis
• Alberto Brizzi
• Daniele Giorgini
• Guido Pella

The following player received the lucky loser spot:

• Karim Maamoun

Filippo Volandri def. Reda El Amrani, 6–3, 6–2

Santiago González / Travis Rettenmaier def. Sadik Kadir / Purav Raja, 6–2, 6–4

• Italian Tennis Federation official website
• ITF search Archived 2010-02-12 at the Wayback Machine