Magnus Norman defeated the defending champion Gustavo Kuerten in the final, 6–3, 4–6, 6–4, 6–4 to win the men's singles tennis title at the 2000 Italian Open.

	Semifinals							Final
	10	Álex Corretja	4	2
	4	Gustavo Kuerten	6	6
								4	Gustavo Kuerten	3	6	4	4
								3	Magnus Norman	6	4	6	6
	3	Magnus Norman	6	6
	9	Lleyton Hewitt	3	0

	First round							Second round							Third round							Quarterfinals
	1	A Agassi	6	77
		T Martin	2	64				1	A Agassi	6	6
	Q	G Gaudio	6	7				Q	G Gaudio	1	4
		F Meligeni	1	5											1	A Agassi	4	4
		S Doseděl	6	3	4										15	D Hrbatý	6	6
		F Squillari	2	6	6				F Squillari	4	63
	Q	J Tarango	4	1				15	D Hrbatý	6	77
	15	D Hrbatý	6	6																		15	D Hrbatý	1	65
	10	Á Corretja	6	4	77																	10	Á Corretja	6	77
		K Kučera	2	6	65			10	Á Corretja	6	77
		T Haas	65	62					J Novák	3	64
		J Novák	77	77											10	Á Corretja	6	6
	WC	L Tieleman	5	3												F Santoro	2	3
		F Santoro	7	6					F Santoro	77	4	6
		B Black	65	4				8	T Henman	65	6	4
	8	T Henman	77	6

	First round							Second round							Third round							Quarterfinals
	4	G Kuerten	6	6
		J Golmard	4	1				4	G Kuerten	6	6
		M Philippoussis	6	1	77				M Philippoussis	2	2
		M Rosset	3	6	62										4	G Kuerten	w/o
		R Krajicek	4	4											14	Y El Aynaoui
		M Zabaleta	6	6					M Zabaleta	6	62	66
		V Spadea	2	3				14	Y El Aynaoui	3	77	78
	14	Y El Aynaoui	6	6																		4	G Kuerten	6	7
	12	P Rafter	6	4	3																		Á Costa	4	5
	Q	B Ulihrach	3	6	6			Q	B Ulihrach	1	2
	Q	A Portas	2	3					Á Costa	6	6
		Á Costa	6	6												Á Costa	6	6
	Q	G Ivanišević	4	6	5											F Clavet	3	2
		F Clavet	6	3	7				F Clavet	7	6
		T Johansson	4	5				6	N Lapentti	5	4
	6	N Lapentti	6	7

	First round							Second round							Third round							Quarterfinals
	5	C Pioline	6	6
		C Woodruff	1	1				5	C Pioline	6	1	65
		N Escudé	1	6	3			Q	A Pavel	3	6	77
	Q	A Pavel	6	4	6										Q	A Pavel	4	2
	Q	J I Chela	3	3												F Mantilla	6	6
		F Mantilla	6	6					F Mantilla	7	65	6
		M Safin	6	6					M Safin	5	77	3
	11	M Ríos	1	4																			F Mantilla	4	3
	13	G Rusedski	3	1																		3	M Norman	6	6
		F Vicente	6	6					F Vicente	2	5
		A Medvedev	3	6	7				A Medvedev	6	7
		R Federer	6	3	5											A Medvedev	64	1
	Q	C Ruud	3	1											3	M Norman	77	6
		C Moyà	6	6					C Moyà	4	2
		S Grosjean	3	62				3	M Norman	6	6
	3	M Norman	6	77

	First round							Second round							Third round							Quarterfinals
	7	T Enqvist	6	6
		D Vacek	1	2				7	T Enqvist	2	6	6
		W Ferreira	6	2	65				M Chang	6	4	2
		M Chang	4	6	77										7	T Enqvist	66	6	3
		A di Pasquale	6	6											9	L Hewitt	78	2	6
		K Alami	3	2					A di Pasquale	3	78	4
		S Koubek	4	2				9	L Hewitt	6	66	6
	9	L Hewitt	6	6																		9	L Hewitt	6	3	6
	16	J C Ferrero	6	65	7																		M Puerta	3	6	1
	WC	D Sanguinetti	4	77	5			16	J C Ferrero	77	6
		H Arazi	6	6					H Arazi	63	3
		S Schalken	3	2											16	J C Ferrero	65	6	4
		M Puerta	6	6												M Puerta	77	3	6
	WC	R Furlan	2	3					M Puerta	6	6
	WC	A Gaudenzi	3	6	5			2	Y Kafelnikov	4	4
	2	Y Kafelnikov	6	2	7

• ATP Singles draw
• Qualifying draw