110th Street may refer to:
Streets
- 110th Street (Manhattan), a major east–west street in Manhattan, New York City
Stations
- Cathedral Parkway–110th Street (IRT Broadway–Seventh Avenue Line), serving the 1 train
- Cathedral Parkway–110th Street (IND Eighth Avenue Line), serving the A, B, and C trains
- Central Park North–110th Street (IRT Lenox Avenue Line), serving the 2 and 3 trains
- 110th Street (IRT Lexington Avenue Line), serving the 4, 6, and <6> trains
- 110th Street (IRT Ninth Avenue Line), former station
Other
- Across 110th Street, a 1972 American action-crime film
- "Across 110th Street", a song by Bobby Womack from the soundtrack and film of the same name.