l-Dopaquinone also known as o-dopaquinone is a metabolite of L-DOPA (L-dihydroxyphenylalanine) and a precursor of melanin.[1][2]
Biosynthesis of melanin occurs in melanocytes, where tyrosine is converted into DOPA and then dopaquinone, which goes on to be formed into pheomelanin or eumelanin.[3]
References
- ^ Ito S, Wakamatsu K (2008). "Chemistry of mixed melanogenesis – pivotal roles of dopaquinone". Photochem. Photobiol. 84 (3): 582–92. doi:10.1111/j.1751-1097.2007.00238.x. PMID 18435614.
- ^ Hearing VJ (2011). "Determination of melanin synthetic pathways". J. Invest. Dermatol. 131 (E1): E8 – E11. doi:10.1038/skinbio.2011.4. PMC 6944209. PMID 22094404.
- ^ Schlessinger, Daniel I.; Schlessinger, Joel (January 2020). "Biochemistry, Melanin". StatPearls Publishing. PMID 29083759. Retrieved 22 May 2020.
External links
- dopaquinone at the U.S. National Library of Medicine Medical Subject Headings (MeSH)