Reilly Opelka defeated Jenson Brooksby in the final, 7–6^(7–5), 7–6^(7–3) to win the singles title at the 2022 Dallas Open. This was the first edition of the tournament.^[1]

The 24–22 second set tiebreak between Opelka and John Isner in the semifinals was the longest tiebreak in a tour-level match since the ATP Tour started in 1990.^[2]

The top four seeds received a bye into the second round.

	Semifinals							Final
	7	Marcos Giron	4	77	65
	4	Jenson Brooksby	6	64	77
								4	Jenson Brooksby	65	63
								2	Reilly Opelka	77	77
	3	John Isner	67	622
	2	Reilly Opelka	79	724

	First round							Second round							Quarterfinals							Semifinals
								1	T Fritz	6	6
		O Otte	4	4				WC	J Sock	1	4
	WC	J Sock	6	6											1	T Fritz	4	6	63
	Q	L Broady	6	6											7	M Giron	6	3	77
		P Gojowczyk	1	4				Q	L Broady	6	3	1
		T Sandgren	4	4				7	M Giron	3	6	6
	7	M Giron	6	6																		7	M Giron	4	77	65
																						4	J Brooksby	6	64	77
								4	J Brooksby	6	3	6
		D Altmaier	6	3	4				A Seppi	3	6	3
		A Seppi	4	6	6										4	J Brooksby	6	6
		F López	5	3												J Thompson	3	0
		J Thompson	7	6					J Thompson	7	77
		J Millman	5	63				8	B Nakashima	5	61
	8	B Nakashima	7	77

	First round							Second round							Quarterfinals							Semifinals
	6	M Cressy	63	6	1
	Q	J Rodionov	77	4	6			Q	J Rodionov	77	66	2
	Q	V Pospisil	6	6				Q	V Pospisil	63	78	6
	WC	C Chakravarthi	1	0											Q	V Pospisil	4	4
		K Anderson	6	6											3	J Isner	6	6
		S Querrey	4	4					K Anderson	61	79	65
								3	J Isner	77	67	77
																						3	J Isner	67	622
	5	A Mannarino	62	6	77																	2	R Opelka	79	724
		S Johnson	77	2	62			5	A Mannarino	6	6
	WC	M Krueger	4	4					Y Nishioka	3	1
		Y Nishioka	6	6											5	A Mannarino	3	4
	Q	C-M Stebe	79	3	6										2	R Opelka	6	6
		D Kudla	67	6	3			Q	C-M Stebe	63	68
								2	R Opelka	77	710

	First round							Qualifying competition
	1	Vasek Pospisil	7	6
		Yasutaka Uchiyama	5	3
								1	Vasek Pospisil	6	77
								6	Christopher Eubanks	3	63
	PR	J. J. Wolf	77	2	4
	6	Christopher Eubanks	65	6	6

	First round							Qualifying competition
	2	Liam Broady	5	78	711
	PR	Denis Istomin	7	66	69
								2	Liam Broady	6	6
								Alt/8	Thomas Fabbiano	2	3
	WC	Adam Neff	1	4
	Alt/8	Thomas Fabbiano	6	6

	First round							Qualifying competition
	3	Jurij Rodionov	77	6
	WC	Liam Krall	61	3
								3	Jurij Rodionov	4	6	6
								7	Jason Jung	6	2	3
	PR	Go Soeda	6	1	66
	7	Jason Jung	3	6	78

	First round							Qualifying competition
	4	Ernesto Escobedo	4	77	64
	Alt	Yosuke Watanuki	6	65	77
								Alt	Yosuke Watanuki	77	4	4
								PR	Cedrik-Marcel Stebe	63	6	6
	PR	Cedrik-Marcel Stebe	3	6	6
	5	Bjorn Fratangelo	6	2	4

• Main draw
• Qualifying draw