Luca or LUCA may refer to:

• Luca (masculine given name), including a list of people
• Luca (feminine given name), including a list of people
• Luca (surname), including a list of people

• The ancient name of Lucca, an Etruscan city of Roman Italy
• Luka (Bor), a village in Serbia known as Luca in Romanian

• Luca Brasi, a feared enforcer in Mario Puzo's 1969 novel The Godfather (and its film adaptation)
• Luca (Yu-Gi-Oh! 5D's), in the anime series
• Luca (Final Fantasy character)
• Luca Paguro, the protagonist in the 2021 film Luca
• Luca (The Bear)

• Luca (Final Fantasy setting), of the video games
• Luca Family Singers, US
• Luca (2019 film), in Indian Malayalam-language
• Luca (2021 film), Disney/Pixar animation
• A song by Brand New from the album The Devil and God Are Raging Inside Me
• Luca, a scrub jay from Angry Birds Stella and the animation

• Luca (genus), moths in the family Notodontidae
• Last universal common ancestor, of all organisms on Earth

• London Universities and Colleges Athletics
• Slang for 1,000 pesos in southern South America

• "Luca$", an episode of The Simpsons
• de Luca, a surname
• Luqa, a town in Malta
• Lucca (disambiguation)
• Luka (disambiguation)
• San Luca (disambiguation)