Chemical compound
Pharmaceutical compound
Tosagestin (INN Tooltip International Nonproprietary Name , USAN Tooltip United States Adopted Name ) (developmental code name ORG-30659 ), also known as 11-methylene-δ15 -norethisterone or 17α-ethynyl-11-methylene-19-nor-δ15 -testosterone , is a progestin of the 19-nortestosterone group which was under development by Organon in the United States and Europe as a hormonal contraceptive (in combination with ethinylestradiol ) and for the treatment of menopausal symptoms but was never marketed.[ 2] [ 3] [ 4] [ 5] [ 6]
See also
References
^ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey) ISBN 978-3-527-30247-5 . ^ World Health Organization (2013), The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances (PDF) , p. 95, archived from the original (PDF) on August 8, 2016 ^ "Tosagestin" , AdisInsight , Springer Nature Switzerland AG, retrieved 12 July 2016 ^ Verhoeven CH, Krebbers SF, Wagenaars GN, Booy CJ, Groothuis GM, Olinga P, Vos RM (November 1998). "In vitro and in vivo metabolism of the progestagen Org 30659 in several species" . Drug Metabolism and Disposition . 26 (11): 1102– 1112. PMID 9806953 . ^ de Visser SJ, Uchida N, van Vliet-Daskalopoulou E, Fukazawa I, van Doorn MB, van den Heuvel MW, et al. (September 2003). "Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE)". Contraception . 68 (3): 195– 202. doi :10.1016/S0010-7824(03)00140-9 . PMID 14561540 . ^ Obruca A, Korver T, Huber J, Killick SR, Landgren B, Struijs MJ (July 2001). "Ovarian function during and after treatment with the new progestagen Org 30659" . Fertility and Sterility . 76 (1): 108– 115. doi :10.1016/S0015-0282(01)01824-6 PMID 11438328 .
PR Tooltip Progesterone receptor
Agonists
Testosterone derivatives: Progestins: 6,6-Difluoronorethisterone 6,6-Difluoronorethisterone acetate 17α-Allyl-19-nortestosterone Allylestrenol Altrenogest Chloroethynylnorgestrel Cingestol Danazol Desogestrel Dienogest Ethinylandrostenediol
Ethisterone Ethynerone Etonogestrel Etynodiol Etynodiol diacetate Gestodene Gestrinone Levonorgestrel Levonorgestrel esters (e.g., levonorgestrel butanoate )Lynestrenol Lynestrenol phenylpropionate Metynodiol Metynodiol diacetate Norelgestromin Norethisterone (norethindrone) Norethisterone esters (e.g., norethisterone acetate , norethisterone enanthate )Noretynodrel Norgesterone Norgestimate Norgestrel Norgestrienone Norvinisterone Oxendolone Quingestanol Quingestanol acetate Tibolone Tigestol Tosagestin ; Anabolic–androgenic steroids: 11β-Methyl-19-nortestosterone 11β-Methyl-19-nortestosterone dodecylcarbonate 19-Nor-5-androstenediol 19-Nor-5-androstenedione 19-Nordehydroepiandrosterone Bolandiol Bolandiol dipropionate Bolandione Dimethisterone Dienedione Dienolone Dimethandrolone Dimethandrolone buciclate Dimethandrolone dodecylcarbonate Dimethandrolone undecanoate Dimethyldienolone Dimethyltrienolone Ethyldienolone Ethylestrenol (ethylnandrol) Methyldienolone Metribolone (R-1881) Methoxydienone (methoxygonadiene) Mibolerone Nandrolone Nandrolone esters (e.g., nandrolone decanoate , nandrolone phenylpropionate )Norethandrolone Normethandrone (methylestrenolone, normethandrolone, normethisterone) RU-2309 Tetrahydrogestrinone Trenbolone (trienolone) Trenbolone esters (e.g., trenbolone acetate , trenbolone enanthate )Trendione Trestolone Trestolone acetate MixedSPRMs Tooltip Selective progesterone receptor modulators ) Antagonists
mPR Tooltip Membrane progesterone receptor PAQR Tooltip Progestin and adipoQ receptor )
