The Spice Islands, now known as the Maluku Islands, are an archipelago in the eastern part of Indonesia.
Spice Island, Island of Spice, or Spice Isle may also refer to:
- Zanzibar Archipelago off the coast of mainland Tanzania, Africa
- Grenada in the Antilles
- Portsmouth Point, in Portsmouth, Hampshire, England
- Spice Islands (brand), an American brand of spice