Seydou is the Francophonic-orthography variant of the Arabic name Sa'id, commonly used in West Africa.

Notable people with the name include:

• Seydou Barry (1943–2007), Senegalese painter
• Seydou Bouda (born 1958), Burkinabé politician and US Ambassador
• Seydou Diarra (1933–), Ivorian political figure, Prime Minister in 2000 and from 2003 to 2005
• Seydou Doumbia (born 1987), Ivorian footballer
• Seydou Badjan Kanté (born 1981), former Ivory Coast-born football defender
• Seydou Keita (footballer) (born 1980), Malian professional footballer
• Seydou Keïta (photographer) (1921–2001), self-taught portrait photographer from Bamako
• Seydou Koné (born 1983), Ivorian professional football player
• Seydou Badian Kouyaté (born 1928), Malian writer and politician
• Seydou Njoya (1902–1992), ruled the Bamum people of Cameroon from 1933 to 1992
• Seydou Traoré (born 1970), former Burkinabé footballer

• Mohamed Seydou Dera (born 1986), Côte d'Ivoire footballer
• Pape Seydou Diop (born 1979), Senegalese international footballer

• Chris Seydou (1949–1994), Malian fashion designer
• Mayaki Seydou (born 1949), former Nigerien bantamweight boxer