Sekou, also spelled Sékou or Seku, is a given name from the Fula language. It is equivalent to the Arabic Sheikh. People with this name include:

• Sekou (singer), British singer

• Seku Amadu (1776–1845), also known as Sékou Amadou or Sheikh Amadu, founder of the Massina Empire in Mali
• Ahmed Sékou Touré (1922–1984), first president of Guinea (1958–1984)
• Sekou Sundiata (1948–2007), African-American poet and performer at The New School in New York City
• Sekou Conneh (born 1960), Liberian politician and former rebel leader
• Sékou Dramé (born 1973), Guinean football player
• Sékou Berthé (born 1977), Malian football defender who last played for Persepolis in Iran Pro League
• Sékou Fofana (born 1980), Malian football defender who plays for FC Banants in Armenian Premier League
• Sékou Tidiane Souaré (born 1983), Ivorian football player, who currently plays for B36 Tórshavn
• Sekou Baradji (born 1984), French football midfielder
• Sékou Camara (footballer, born 1985) (1985–2013), Malian footballer
• Sekou Cissé (born 1985), Côte d'Ivoire football striker
• Sekou Bagayoko (born 1987), Malian professional football player who plays for Jeunesse Sportive de la Saoura
• Sekou Jabateh Oliseh (born 1990), Liberian international footballer who plays professionally for Russian side Kuban Krasnodar
• Sekou Bangoura (born 1991), American tennis player
• Sékou Baradji (born 1995), French football forward
• Sekou Lumumba, Canadian rock musician
• Sekou Odinga, born Nathanial Burns, American activist who was imprisoned for actions with the Black Liberation Army
• Sékou Traoré, filmmaker from Burkina Faso
• Sekou Smith, American sportswriter
• Hakeem Sekou Jeffries, American politician, Representative for New York's 8th congressional district

• Lasana M. Sekou (born 1959), writer from Saint Martin
• Malik Sekou (born 1964), academic from the United States Virgin Islands

• Sékou, Benin, a town and arrondissement in the Atlantique Department of southern Benin