Great Void can refer to:

Astronomy

• A "super void", large empty regions of spaces

• Boötes Void, a supervoid in Boötes constellation
• Giant Void, a supervoid in the Canes Venatici constellation
• CMB cold spot, a supervoid in Eridanus constellation

• Outer space in general

Other

• At the Edge of the Great Void, the nineteenth volume of the Valérian and Laureline series
• A region in the Crystalicum RPG card game
• "Eoarchaean: The Great Void", a song by The Ocean Collective, from the album Precambrian
• Greetings from the Great Void, an album from the Italian duo My Cat Is an Alien
• Purgatory in the after-life