F16, F 16, F-16 or FI6 may refer to:

• General Dynamics F-16 Fighting Falcon, a 1974 American multirole fighter jet aircraft
• FI6 (antibody), an antibody that targets influenza A viruses
• F 16 Uppsala, a Swedish air force base
• Formula 16, a 5-metre catamaran
  • Nacra F16 a Formula 16 catamaran design
• Volvo F16, a truck
• Half-precision floating-point format, a 16-bit computer number format
• Shibuya Station, a railway station in Tokyo, coded as F16 on the Fukutoshin Line
• Fluorine-16 (F-16 or ¹⁶F), an isotope of fluorine

• F-16 Rachanon (born 1991), Thai kickboxer