The Amstel is a river in North Holland, the Netherlands.
Amstel may also refer to:
- Amstel Brewery, a Dutch beer brewery
- Amstel Gold Race, a road bicycle race
- Amstel House, New Castle, Delaware, US
- Amstel Playwright of the Year Award, a South African award, discontinued in 1994
- Amstel Tijgers, an ice hockey team from Amsterdam
- Amsterdam Airlines (ATC radio callsign "Amstel")
- Amsterdam Amstel railway station, also a metro station
- Van Amstel, a medieval dynasty which held the lordship of the area around the Amstel river
- Jan van Amstel class minesweeper, a class of nine minesweepers of the Royal Netherlands Navy
- Nieuw-Amstel ("New Amstel"), the former name of New Castle, Delaware during the 17th century when it was a Dutch colony