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Fifth Avenue is a major thoroughfare in Manhattan, New York City.

Fifth Avenue may also refer to:

Streets

Several New York City Subway stations in Manhattan:
- Fifth Avenue–59th Street (BMT Broadway Line), at 59th Street; serving the N, R, and W trains
- Fifth Avenue/53rd Street (IND Queens Boulevard Line), at 53rd Street; serving the E and M trains
- Fifth Avenue (IRT Flushing Line), at 42nd Street; serving the 7 and <7> trains
Fifth Avenue Line (Brooklyn elevated), demolished Brooklyn–Manhattan Transit Corporation rapid transit line
Fifth Avenue Line (Brooklyn surface), a singular bus route in Brooklyn
Madison and Fifth Avenues buses, several bus routes in Manhattan
Fifth Avenue Bus Company, a former double-decker manufacturer
Fifth Avenue Coach Company and Surface Transit, a former bus operator in Manhattan
5th Avenue station (LRT), a train station on the Manila LRT Line 1 in Caloocan, Philippines
5th Avenue station (PNR), a train station on the Philippine National Railways in Caloocan, Philippines

5th Avenue (candy), a candy bar introduced in 1936
Chrysler Fifth Avenue, a large car
Saks Fifth Avenue, department store chain in the United States
Fifth Avenue High School, Pittsburgh, Pennsylvania
Fifth Avenue Vietnam Peace Parade Committee, an anti-war parade coordinator during the mid-1960s
5th Avenue (album), an album by Christina Aguilar
5th Avenue Cinema, a projection theater in Portland, Oregon
5th Avenue Theatre, a landmark theatre building located in Seattle, Washington
Fifth Avenue Theatre, a Broadway theatre in New York City demolished in 1939
Fifth Avenue (film), a 1926 American silent drama film
Avenue 5, a 2020 comedy series
"5th Avenue", a song by America from Perspective