The 2022 Upper Austria Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mauthausen, Austria between 2 and 8 May 2022.

Country	Player	Rank1	Seed
AUS	John Millman	79	1
CZE	Jiří Lehečka	88	2
COL	Daniel Elahi Galán	105	3
SVK	Norbert Gombos	106	4
MDA	Radu Albot	121	5
GER	Mats Moraing	126	6
CZE	Zdeněk Kolář	137	7
AUT	Dennis Novak	149	8
	Egor Gerasimov	150	9

• ¹ Rankings as of 25 April 2022.^[1]

The following players received wildcards into the singles main draw:

• Gerald Melzer
• Filip Misolic
• Lukas Neumayer

The following player received entry into the singles main draw as an alternate:

• Attila Balázs

The following players received entry from the qualifying draw:

• Nerman Fatić
• Lucas Miedler
• Matej Sabanov
• Nikolás Sánchez Izquierdo
• Alexander Shevchenko
• Máté Valkusz

The following player received entry as a lucky loser:

• Benjamin Hassan

• Jurij Rodionov def. Jiří Lehečka 6–4, 6–4.

• Sander Arends / David Pel def. Johannes Härteis / Benjamin Hassan 6–4, 6–3.