The 2022 Saint-Tropez Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Saint-Tropez, France between 10 and 16 October 2022.

Country	Player	Rank1	Seed
FRA	Hugo Gaston	79	1
FRA	Hugo Grenier	101	2
FRA	Ugo Humbert	104	3
ESP	Fernando Verdasco	115	4
FRA	Grégoire Barrère	116	5
USA	Jack Sock	122	6
AUT	Jurij Rodionov	135	7
FRA	Geoffrey Blancaneaux	142	8
	Alexander Shevchenko	146	9

• ¹ Rankings are as of 3 October 2022.^[1]

The following players received wildcards into the singles main draw:

• Dan Added
• Jurgen Briand
• Luca Van Assche

The following player received entry into the singles main draw using a protected ranking:

• Roberto Marcora

The following player received entry into the singles main draw as a special exempt:

• Nick Hardt

The following players received entry into the singles main draw as alternates:

• Frederico Ferreira Silva
• Louis Wessels

The following players received entry from the qualifying draw:

• Mattia Bellucci
• Salvatore Caruso
• Federico Gaio
• Nicholas David Ionel
• Valentin Royer
• Clément Tabur

The following player received entry as a lucky loser:

• Adrian Andreev

• Mattia Bellucci def. Matteo Arnaldi 6–3, 6–3.

• Dan Added / Albano Olivetti def. Romain Arneodo / Tristan-Samuel Weissborn 6–3, 3–6, [12–10].