The 2022 Orlando Open was a professional tennis tournament played on hard courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Orlando, Florida, United States between June 6 and 12 2022.

Country	Player	Rank1	Seed
USA	J. J. Wolf	125	1
ECU	Emilio Gómez	151	2
USA	Christopher Eubanks	156	3
AUS	Jason Kubler	159	4
USA	Michael Mmoh	175	5
TUR	Altuğ Çelikbilek	179	6
USA	Bjorn Fratangelo	185	7
AUS	Rinky Hijikata	233	8

• ¹ Rankings are as of May 23, 2022.^[1]

The following players received wildcards into the singles main draw:

• Brandon Holt
• Aleksandar Kovacevic
• Ben Shelton

The following players received entry into the singles main draw using protected rankings:

• Andrew Harris
• Wu Yibing

The following players received entry into the singles main draw as alternates:

• Malek Jaziri
• Roberto Quiroz
• Denis Yevseyev

The following players received entry from the qualifying draw:

• Adrian Andreev
• Martin Damm
• Gilbert Klier Júnior
• Matija Pecotić
• Michail Pervolarakis
• Keegan Smith

• Wu Yibing def. Jason Kubler 6–7^(5–7), 6–4, 3–1 ret.

• Chung Yun-seong / Michail Pervolarakis def. Malek Jaziri / Kaichi Uchida 6–7^(5–7), 7–6^(7–3), [16–14].