The 2022 Christus Health Pro Challenge was a professional tennis tournament played on outdoor hard courts. It was the sixth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Tyler, Texas, United States between 24 and 30 October 2022.^[1]

• Taylor Townsend def. Yuan Yue, 6–4, 6–2

• Maria Kozyreva / Ashley Lahey def. Jaeda Daniel / Nell Miller, 7–5, 6–2

Country	Player	Rank1	Seed
EST	Kaia Kanepi	29	1
USA	Madison Brengle	49	2
HUN	Panna Udvardy	81	3
CHN	Yuan Yue	83	4
USA	Katie Volynets	119	5
ROU	Gabriela Lee	147	6
MEX	Marcela Zacarías	162	7
ARG	María Lourdes Carlé	173	8

• ¹ Rankings are as of 17 October 2022.

The following players received wildcards into the singles main draw:

• Hina Inoue
• Sofia Kenin
• Maria Mateas
• Alana Smith

The following player received entry into the singles main draw using a protected ranking:

• Emiliana Arango

The following players received entry from the qualifying draw:

• Alexis Blokhina
• Katarina Kozarov
• Maria Kozyreva
• Ellen Perez
• Abigail Rencheli
• Malaika Rapolu
• Alexandra Vecic
• Allura Zamarripa

• 2022 Christus Health Pro Challenge at ITFtennis.com
• Official website