The 2022 Brest Challenger was a professional tennis tournament played on hard courts. It was the seventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Brest, France between 24 and 30 October 2022.
Singles main-draw entrants
Seeds
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 FRA
|
Benjamin Bonzi | 63 | 1 |
 POR
|
Nuno Borges | 94 | 2 |
| FRA
|
Grégoire Barrère | 111 | 3 |
| FRA
|
Hugo Grenier | 116 | 4 |
 NED
|
Jelle Sels | 140 | 5 |
 ITA
|
Matteo Arnaldi | 141 | 6 |
| FRA
|
Geoffrey Blancaneaux | 147 | 7 |
| FRA
|
Manuel Guinard | 148 | 8 |
- 1 Rankings are as of 17 October 2022.[2]
Other entrants
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Duje Ajduković- Mathias Bourgue
- Kenny de Schepper
Evgeny Donskoy- Sascha Gueymard Wayenburg
- Tristan Lamasine
The following players received entry as lucky losers:
Champions
Singles
- Grégoire Barrère def. Luca Van Assche 6–3, 6–3.
Doubles
Viktor Durasovic / 
Otto Virtanen def. 
Filip Bergevi / 
Petros Tsitsipas 6–4, 6–4.