The women's elite road race at the 2021 European Road Championships took place on 11 September 2021, in Trentino, Italy. Nations were allowed to enter between 1 and 8 riders into the event, dependent on UCI rankings.^[1]

Rank	#	Cyclist[2]	Nation	Time	Diff.
	5	Ellen van Dijk	Netherlands	2:50:35
	26	Liane Lippert	Germany	2:51:53	01:18
	85	Rasa Leleivytė	Lithuania	s.t.
4	40	Katarzyna Niewiadoma	Poland	s.t.
5	7	Demi Vollering	Netherlands	s.t.
6	11	Marta Cavalli	Italy	s.t.
7	52	Marlen Reusser	Switzerland	s.t.
8	87	Alena Amialiusik	Belarus	s.t.
9	6	Annemiek van Vleuten	Netherlands	2:51:56	01:21
10	9	Elisa Balsamo	Italy	2:53:04	02:29
11	20	Lisa Brennauer	Germany	s.t.
12	1	Floortje Mackaij	Netherlands	s.t.
13	76	Eugenia Bujak	Slovenia	s.t.
14	30	Lotte Kopecky	Belgium	s.t.
15	51	Elise Chabbey	Switzerland	s.t.
16	3	Amy Pieters	Netherlands	s.t.
17	2	Riejanne Markus	Netherlands	s.t.
18	47	Juliette Labous	France	s.t.
19	57	Eider Merino Cortazar	Spain	s.t.
20	22	Kathrin Hammes	Germany	s.t.
21	93	Omer Shapira	Israel	s.t.
22	60	Katrine Aalerud	Norway	s.t.
23	77	Urška Žigart	Slovenia	s.t.
24	14	Erica Magnaldi	Italy	2:53:19	02:44
25	38	Marta Lach	Poland	2:54:54	04:19
26	46	Victorie Guilman	France	s.t.
27	67	Tamara Dronova	Russia	s.t.
28	74	Hanna Nilsson	Sweden	2:54:56	04:21
29	64	Mie Bjørndal Ottestad	Norway	2:56:33	05:58
30	25	Corinna Lechner	Germany	2:57:07	06:32
31	61	Susanne Andersen	Norway	s.t.
32	13	Elisa Longo Borghini	Italy	2:57:45	07:10
DNF	4	Chantal van den Broek-Blaak	Netherlands
DNF	8	Marianne Vos	Netherlands
DNF	10	Sofia Bertizzolo	Italy
DNF	12	Tatiana Guderzo	Italy
DNF	15	Soraya Paladin	Italy
DNF	16	Debora Silvestri	Italy
DNF	17	Trine Holmsgaard	Denmark
DNF	18	Marita Jensen	Denmark
DNF	19	Pernille Mathiesen	Denmark
DNF	21	Tanja Erath	Germany
DNF	23	Romy Kasper	Germany
DNF	24	Lisa Klein	Germany
DNF	27	Trixi Worrack	Germany
DNF	28	Valerie Demey	Belgium
DNF	29	Ann-Sophie Duyck	Belgium
DNF	31	Lone Meertens	Belgium
DNF	32	Sara Van de Vel	Belgium
DNF	33	Julie Van de Velde	Belgium
DNF	34	Fien van Eynde	Belgium
DNF	35	Jesse Vandenbulcke	Belgium
DNF	36	Małgorzata Jasińska	Poland
DNF	37	Karolina Karasiewicz	Poland
DNF	39	Aurela Nerlo	Poland
DNF	41	Anna Plichta	Poland
DNF	42	Dorota Przęzak	Poland
DNF	43	Aude Biannic	France
DNF	44	Audrey Cordon-Ragot	France
DNF	45	Eugénie Duval	France
DNF	48	Gladys Verhulst	France
DNF	49	Morgane Coston	France
DNF	50	Caroline Baur	Switzerland
DNF	53	Sandra Alonso	Spain
DNF	54	Ziortza Isasi	Spain
DNF	55	Eukene Larrarte	Spain
DNF	56	Irene Mendez	Spain
DNF	58	Lourdes Oyarbide	Spain
DNF	59	Gloria Rodríguez	Spain
DNF	62	Ingvild Gåskjenn	Norway
DNF	63	Ingrid Lorvik	Norway
DNF	65	Tatiana Antoshina	Russia
DNF	66	Anastasia Chursina	Russia
DNF	68	Seda Krylova	Russia
DNF	69	Margarita Syradoeva	Russia
DNF	70	Sarah Rijkes	Austria
DNF	71	Christina Schweinberger	Austria
DNF	72	Angelika Tazreiter	Austria
DNF	73	Nathalie Eklund	Sweden
DNF	75	Urška Bravec	Slovenia
DNF	78	Yuliia Biriukova	Ukraine
DNF	79	Valeriya Kononenko	Ukraine
DNF	80	Olena Sharha	Ukraine
DNF	81	Olga Shekel	Ukraine
DNF	82	Hanna Solovey	Ukraine
DNF	83	Olivija Baleišytė	Lithuania
DNF	84	Inga Češulienė	Lithuania
DNF	86	Viktorija Senkutė	Lithuania
DNF	88	Zsófia Szabó	Hungary
DNF	89	Nikola Bajgerová	Czech Republic
DNF	90	Jarmila Machačová	Czech Republic
DNF	91	Nikola Nosková	Czech Republic
DNF	92	Rotem Gafinovitz	Israel
DNF	94	Lija Laizāne	Latvia
DNF	95	Tereza Medveďová	Slovakia
DNF	96	Megan Armitage	Ireland
DNF	97	Ellen McDermott	Ireland
DNF	98	Silja Jóhannesdóttir	Iceland
DNF	99	Hafdís Sigurðardóttir	Iceland
DNF	100	Manuela Muresan	Romania
DNF	101	Georgeta Ungureanu	Romania
DNF	102	Varvara Fasoi	Greece