Two-time defending champion Shingo Kunieda won the men's singles wheelchair tennis title at the 2010 US Open after Nicolas Peifer withdrew before the final. It was his third US Open singles title and eleventh major singles title overall.
Seeds
Shingo Kunieda (champion)
Maikel Scheffers (semifinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| Quarterfinals | Semifinals | Finals | ||||||||||||||||||
| 1 | Shingo Kunieda
| 6 | 6 | |||||||||||||||||
| Ronald Vink
| 0 | 0 | ||||||||||||||||||
| 1 | Shingo Kunieda
| 6 | 6 | |||||||||||||||||
 Stéphane Houdet
| 2 | 1 | ||||||||||||||||||
| WC |  Jon Rydberg
| 1 | 4 | |||||||||||||||||
| Stéphane Houdet
| 6 | 6 | ||||||||||||||||||
| 1 | Shingo Kunieda
| |||||||||||||||||||
| Nicolas Peifer
| w/o | |||||||||||||||||||
| Robin Ammerlaan
| 0 | 4 | ||||||||||||||||||
| Nicolas Peifer
| 6 | 6 | ||||||||||||||||||
| Nicolas Peifer
| 7 | 7 | ||||||||||||||||||
| 2 | Maikel Scheffers
| 5 | 63 | |||||||||||||||||
 Stefan Olsson
| 6 | 4 | 2 | |||||||||||||||||
| 2 | Maikel Scheffers
| 4 | 6 | 6 | ||||||||||||||||