Fernando González was the defending champion but lost in the first round to Michal Tabara.

Andy Roddick won in the final 7–5, 6–3 against Hyung-Taik Lee.

A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.

	First round							Second round							Quarterfinals							Semifinals							Final
	1	J-M Gambill	5	6	2
	Q	C Ruud	7	3	6			Q	C Ruud	6	2	5
		S Koubek	64	6	6				S Koubek	4	6	7
		E Kempes	77	3	3											S Koubek	3	1
		R Sluiter	3	4											WC	A Roddick	6	6
	WC	A Roddick	6	6				WC	A Roddick	6	6
		F Meligeni	0	2				5	M Gustafsson	2	4
	5	M Gustafsson	6	6																		WC	A Roddick	77	77
	3	J Golmard	4	6	7																	3	J Golmard	63	62
		K Alami	6	4	5			3	J Golmard	77	6
		G Bastl	4	4					D Sánchez	63	4
		D Sánchez	6	6											3	J Golmard	6	6
	WC	M Russell	5	0												J Vaněk	3	2
		J Vaněk	7	6					J Vaněk	77	77
	Q	I Labadze	6	3	4			7	X Malisse	64	65
	7	X Malisse	2	6	6																								WC	Andy Roddick	7	6
	6	O Rochus	6	6																									8	Hyung-Taik Lee	5	3
	Q	R Ginepri	4	4				6	O Rochus	6	79
	WC	M Fish	4	4					A Gaudenzi	2	67
		A Gaudenzi	6	6											6	O Rochus	4	2
		C Rochus	2	4											4	M Tabara	6	6
	Q	J Blake	6	6				Q	J Blake	6	3	4
		F González	5	4				4	M Tabara	3	6	6
	4	M Tabara	7	6																		4	M Tabara	6	2	1
	8	H-T Lee	6	6																		8	H-T Lee	4	6	6
		A Stoliarov	4	1				8	H-T Lee	6	4	7
		M Larsson	5	6	713				M Larsson	0	6	5
		J Siemerink	7	1	611										8	H-T Lee	6	2	6
		C Woodruff	5	3											2	A Ilie	4	6	2
		A Popp	7	6					A Popp	6	2	65
		L Burgsmüller	3	5				2	A Ilie	4	6	77
	2	A Ilie	6	7

• 2001 U.S. Men's Clay Court Championships Draw
• 2001 U.S. Men's Clay Court Championships Qualifying Draw