The 1980–81 Algerian Cup is the 19th edition of the Algerian Cup. EP Sétif are the defending champions, having beaten USK Alger 1–0 in the previous season's final.
Round of 64
Round of 32
Round of 16
Quarter-finals
| 1981 | USK Alger | 1 – 0 | USM El Harrach | Stade 20 Août 1955, Algiers |
| 1981 | MP Oran | 2 – 1 | IRB Madania |
| 1981 | ASC Oran | 2 – 1 (a.e.t.) | CR Belcourt |
| 1981 | DNC Alger | 1 – 0 | EP Sétif | Stade du 1er Novembre 1954, Tizi Ouzou |
Semi-finals
| 1981 | MP Oran | 1 – 2 | USK Alger | Stade Akid Lotfi, Tlemcen |