The 6th Gran Premio di Napoli was a Formula Two motor race held on 10 May 1953 at Posillipo, Naples. The race was run over 60 laps of the circuit, and was won by Italian driver Giuseppe Farina in a Ferrari 500, starting from pole. Maserati teammates Juan Manuel Fangio and José Froilán González were second and third, both driving a Maserati A6GCM. Alberto Ascari set fastest lap in a Ferrari 500 but finished in fifth place, five laps down. ^{[1] [2]}

Pos	Driver	Entrant	Constructor	Time/Position	Grid
1	Giuseppe Farina	Scuderia Ferrari	Ferrari 500	2:12:17.10, 111.58 kph	1
2	Juan Manuel Fangio	Officine Alfieri Maserati	Maserati A6GCM	+18.30s	3
3	José Froilán González	Officine Alfieri Maserati	Maserati A6GCM	+22.53s	4
4	Luigi Villoresi	Scuderia Ferrari	Ferrari 500	+1 lap	5
5	Alberto Ascari	Scuderia Ferrari	Ferrari 500	+5 laps	2
NC	Raffaele Argenziano	Raffaele Argenziano	Paganelli-Fiat	+8 laps	6
Ret	Rodolfo d'Apuzzo	Guglielmo Esposito	Camen-Fiat	22 laps, axle	7
Ret	Giuseppe Ruggiero	Giuseppe Ruggiero	Maserati A6GCS	4 laps	8