Year 169 (CLXIX) was a common year starting on Saturday of the Julian calendar. At the time, it was known as the Year of the Consulship of Senecio and Apollinaris (or, less frequently, year 922 Ab urbe condita). The denomination 169 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.

• Marcomannic Wars: Germanic tribes invade the frontiers of the Roman Empire, specifically the provinces of Raetia and Moesia.
• Northern African Moors invade what is now Spain.
• Marcus Aurelius becomes sole Roman Emperor upon the death of Lucius Verus.
• Marcus Aurelius forces his daughter Lucilla into marriage with Claudius Pompeianus.
• Galen moves back to Rome for good.

• Confucian scholars who had denounced the court eunuchs are arrested, killed or banished from the capital of Luoyang and official life during the second episode of the Disasters of Partisan Prohibitions, which does not formally end until 184 with the onslaught of the Yellow Turban Rebellion.

• Pertinax succeeds Alypius as bishop of Byzantium.
• Theophilus of Antioch becomes patriarch of Antioch.

• Lucian demonstrates the absurdity of fatalism.

• Jingū, Japanese empress and regent (d. 269)
• Zhang Liao, Chinese general (d. 222)

• January 23 – Lucius Verus, Roman emperor (b. 130)^[1]
• September 10 – Marcus Annius Verus, Roman co-ruler
• Alypius, bishop of Byzantium (approximate date)
• Li Ying, Chinese scholar and politician