Santa Lucia may refer to:

• Abbey of Santa Lucia, a medieval abbey in the comune of Rocca di Cambio, Abruzzo, central Italy
• Monastero di Santa Lucia, Adrano, a former Benedictine monastery in Catania, Italy
• Santa Lucia, Parma, a Baroque-style Roman Catholic church located in Parma, region of Emilia Romagna, Italy
• Santa Lucia, Venice, a church in Venice, northern Italy, demolished in 1861
• Santa Lucia in Selci, an ancient Roman Catholic church in Rome, Italy

• Santa Lucia (film), a 1956 West German musical comedy film
• "Santa Lucia" (song), a traditional Neapolitan song
• "Santa Lucia luntana", a Neapolitan song
• "Santa Lucia", a song written by Roque Narvaja, and popularized by Miguel Ríos

• Santa Lucía, Corrientes
• Santa Lucía Department
• Santa Lucía River (Argentina)
• Santa Lucía, Buenos Aires

• Santa Lúcia, Paraná

• Santa Lucía Hill, Santiago

• Santa Lucía, Atlántico

• Santa Lucía (Minas de Matahambre)

• Santa Lucía Canton

• Santa-Lucia-di-Mercurio, a commune in the Haute-Corse department of France on the island of Corsica
• Santa-Lucia-di-Moriani, a commune in the Haute-Corse department of France on the island of Corsica

• Santa Lucía Cotzumalguapa
• Santa Lucía Milpas Altas
• Santa Lucía La Reforma
• Santa Lucía Utatlán

• Santa Lucía, Francisco Morazán
• Santa Lucía, Intibucá

• Santa Lucia (Siniscola), part of the municipality of Siniscola in Sardinia (Italy)
• Santa Lucia or Borgo Santa Lucia, historic waterfront district of Naples
• Santa Lucia, Città di Castello, a frazione of the comune of Città di Castello in the Province of Perugia, Umbria, central Italy
• Santa Lucia (Verona), an ancient paesino next to Verona
• Santa Lucia del Mela, a municipality in the Metropolitan City of Messina in the Italian region Sicily
• Santa Lucia di Piave, a comune in the province of Treviso, Veneto, north-eastern Italy
• Santa Lucia di Serino, a town and comune in the province of Avellino, Campania, southern Italy.

• Santa Luċija, a village

• Santa Lucía, Zumpango
  • Santa Lucía Airport
• Santa Lucia (Monterrey), an early Spanish settlement in Monterrey
• Santa Lucía riverwalk, an artificial river in Monterrey
• Santa Lucía del Camino, Oaxaca
• Santa Lucía Miahuatlán, Oaxaca
• Santa Lucía Monteverde, Oaxaca
• Santa Lucía Ocotlán, Oaxaca

• Santa Lucía, Boaco

• Santa Lucía, Chiriquí

• Santa Lucia, Ilocos Sur
• Santa Lucia Protected Landscape, a protected area in Ilocos Sur

• Santa Lucía de Tirajana, Canary Islands

• Santa Lucia Range, mountains in central California
• Santa Lucia Highlands AVA, California wine region in Monterey County, California
• Santa Lucia Preserve, a private conservation community
• Santa Lucia (Spanish Florida) – Short-lived fort in Spanish Florida

• Santa Lucía, Uruguay, a city in Canelones Department
• Santa Lucía River
• Santa Lucía del Este, a seaside resort in Canelones Department

• Santa Lucía, Miranda

• Santa Lucia lupine, a plant native to California

• Sta. Lucia Realtors, a basketball team in the Philippines
• Sta. Lucia East Grand Mall, a shopping mall in Cainta, Rizal, Philippines
• Battle of Santa Lucia, a battle of the First Italian War of Independence in 1848
• Saint Lucy, 3rd-century Christian saint also known as Santa Lucia

• Santa Lucía station (disambiguation)
• Lucia (disambiguation)
• Lucian (disambiguation)
• Saint Lucia (disambiguation)
• Saint Lucian (disambiguation)
• Saint Lucie (disambiguation)
• Saint Lucy (disambiguation)
• Santa Luzia (disambiguation)
• St. Lucie (disambiguation)