Resident Evil 4 is a 2005 video game.

RE4 or RE 4 may also refer to:

• • Resident Evil 4 (2023 video game), a remake to the above game
  • Resident Evil: Afterlife, the fourth film in the live action series
  • Resident Evil: Death Island, the fourth film in the animated series
• the Wupper-Express (RE 4), a rail service in Germany
• the RegioExpress route RE4, a rail service in Switzerland
• RE4, a chassis code for Honda CR-V (third generation)
• (10594) 1996 RE4, a minor planet