McPhail or MacPhail is a surname. Notable people with the surname include:

• Addie McPhail (1905–2003), American film actress
• Alastair McPhail, British diplomat, the first British ambassador to South Sudan
• Alexander James McPhail (1883-1931), Scottish-Canadian agricultural reformer
• Andy McPhail, Scottish rugby league footballer who played in the 2000s
• Billy McPhail (1928–2003), Scottish footballer
• Bob McPhail (1905–2000), Scottish international footballer
• Bob McPhail, English rugby union, and rugby league footballer who played in the 1900s
• Bruce McPhail (1937–2020), New Zealand rugby player
• Dan McPhail (1903–1987), Scottish professional footballer
• David McPhail (1886–?), New Zealand rugby league footballer who played in the 1900s and 1910s
• David McPhail (1945–2021), New Zealand actor
• Donna McPhail, British comedian, TV presenter, journalist
• Douglas McPhail (1914–1944), American actor and singer
• George Wilson McPhail (1815–1871), Presbyterian minister, president of Lafayette College, and Davidson College.
• Hal McPhail (1912–1977), American football player
• Jerris McPhail (born 1972), former professional American football player
• John McPhail (disambiguation)
• Larry McPhail (born 1968), retired American soccer forward
• Malcolm McPhail (1895–1975), Scottish footballer
• Marnie McPhail (born 1966), Canadian-American actress
• Michael McPhail (born 1981), American Olympic rifle shooter
• Sharon McPhail (born 1948), American lawyer and politician
• Stephen McPhail (born 1979), Republic of Ireland international footballer

• Agnes Macphail (1890–1954), Canadian feminist and first woman to be elected to the Canadian House of Commons.
• Alesha MacPhail, murder victim
• Andrew Macphail (1864–1938), Canadian physician, author, professor of medicine and soldier.
• Andy MacPhail (born 1953), president of baseball operations for the Baltimore Orioles and son of the former American League president Lee MacPhail and grandson of Larry MacPhail.
• Angus MacPhail (1903–1962), English screenwriter known for his work with Alfred Hitchcock; credited with the creation of the term "MacGuffin"
• Catherine Macphail (born 1964), Scottish-born author
• Dan Macphail, fictitious engineer of the Vital Spark
• Dugald MacPhail (1818-1887) Gaelic songwriter, poet and author from Strathcoil on Mull^[1]
• Dugald MacPhail, one of the last survivors of the Battle of Isandlwana in 1879 when serving as part of the Buffalo Border Guard^[2]
• Iain Macphail, Lord Macphail (1938–2009) Scottish lawyer, Senator of the College of Justice, Judge of the Supreme Court
• John MacPhail (born 1955), former Scottish footballer
• Joy MacPhail (born 1952), former Canadian New Democratic Party of British Columbia politician
• Katherine Stewart MacPhail (1887-1974), Scottish Surgeon
• Larry MacPhail (1890–1975), American executive and innovator in Major League Baseball
• Lee MacPhail (1917–2012), former administrator in Major League Baseball
• Mark MacPhail (died 1989), police officer and murder victim
• Robert Lloyd George MacPhail (1920–1995), Canadian politician and the 36th Lieutenant Governor of Prince Edward Island; Member of the Order of Canada
• William S. MacPhail (fl. 1900s), namesake of the MacPhail Center for Music in Minneapolis, Minnesota

• Mount McPhail, Canada
• Cobden/Bruce McPhail Memorial Airport, Ontario, Canada
• McPhail Angus Farm
• McPhail Memorial Baptist Church, Ottawa, Canada
• Fergus McPhail, Australian children's television programme
• McPhail v Doulton (1970), landmark English trusts law decision by the House of Lords
• Paul, a surname
• Clan MacPhail, the Sons of Paul, a Scottish highland clan
• Gordon & MacPhail whisky
• Southern Alberta Institute of Technology MacPhail School of Energy^[3]