Kvaček or Kvacek is a Czech surname and can refer to:

• Jiří Kvaček [species], Czech botanist
• Karel Kváček (1912–1986), Czech wrestler
• Milan Kvaček [Wikidata], Czech researcher, Institute of Ore Research, Kutna Hora
• Milouš Kvaček (1933–2010), Czechoslovak professional football player
• Robert Kvaček [cs; commons] (1932–2024), Czech historian
• Zlatko Kvaček [species] (1937-2020), Czech palaeobotanist