4-HO-NET, also known as 4-hydroxy-N-ethyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT).^[1] It was not included by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.^[2] The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT_2A receptor.^[1] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lower potency than psilocin (4-HO-DMT).^[1] Unlike 4-HO-NET, norpsilocin is notably inactive in this test.^[1] In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents.^[1] 4-HO-NET was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.^[1]

• Substituted tryptamine
• 4-HO-DET (ethocin)

• 4-HO-NET - Isomer Design