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Hi everyone!

I'm a chemistry major that has been assigned to edit this wikipedia page for the next few months. I'm looking to add on to the "biosynthesis in the body" section as well as create a new sub heading on hydrogen sulfide's significance in cellular signaling. Recent research has shown that hydrogen sulfide has an extremely wide range of physiological and pathological processes it coordinates such as anti-inflammation, anti-tumor as well as cardiovascular protection. I wanted to introduce a few sources that I plan to supplement the page with over time! Here you go please let me know what you think of these sources:

1. Rose, Peter; Moore, Philip K.; Zhu, Yi Zhun (14 November 2016). "H2S biosynthesis and catabolism: new insights from molecular studies". Cellular and Molecular Life Sciences. 74 (8): 1391–1412. doi:10.1007/s00018-016-2406-8.
2. Wallace, John L.; Wang, Rui (7 April 2015). "Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter". Nature Reviews Drug Discovery. 14 (5): 329–345. doi:10.1038/nrd4433.
3. Wang, Rui (November 2002). "Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?". The FASEB Journal. 16 (13): 1792–1798. doi:10.1096/fj.02-0211hyp.{{cite journal}}: CS1 maint: unflagged free DOI (link)

--Nkopplin (talk) 01:11, 28 September 2018 (UTC)[reply]

I came to this talk page to complain about the lack of detail in this article concerning the enzymes/processes that H
₂S interacts with. Specifically, the article has no information on which enzymes are responsible for the detoxification of H
₂S – hydrogen-sulfide S-acetyltransferase? sulfide:quinone reductase? sulfite oxidase? sulfur dioxygenase? – nor what it is detoxified into – thioacetate? – nor the specific enzyme(s) it affects to cause poisoning (just "mitochondrial cytochrome"). Also, it states that death is caused by CNS stimulation, but does not explain the mechanism by which H
₂S causes this stimulation. Nkopplin, if you want to improve the article I suggest starting there; Sulfur metabolism § Oxidation may be of use, although it is poorly referenced. As it stands, this article is a hodgepodge of random bits of information strewn across very poorly categorised sections. 121.217.97.142 (talk) 09:47, 6 October 2018 (UTC)[reply]

Nkopplin. Your sources listed above may be appropriate for a term paper review or journal article, but do not provide proof of concept expected for an encyclopedia. See WP:NOTJOURNAL, #6-8. The hydrogen sulfide literature is highly speculative about its biological role in vivo. Better to briefly discuss (supported by reviews) its synthesis, preliminary biochemistry, etc. The topic is years away from understanding what it may be doing in vivo, a discussion requiring WP:MEDRS reviews on human studies which are not available yet. --Zefr (talk) 16:44, 6 October 2018 (UTC)[reply]

This revert was justified because there is no concluded research to report in the article. We can report research when there is actual information to inform users that hydrogen sulfide has an effect which is reviewed and published in a medical journal per WP:MEDRS. Zefr (talk) 17:34, 26 February 2021 (UTC)[reply]

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Nkopplin.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:07, 17 January 2022 (UTC)[reply]

Not a huge deal, but it struck me as odd to include the shape of such a simple molecule. I don't believe I've seen "molecular shape" listed as a property for any molecule in the 15 or so years I've been coming here.

I understand stereochemistry, steric hindrance, etc are very important with larger, organic molecules. But even in that context, you're not going to describe the shape of the molecule as if it's a crystal, with a finite set of limited shapes possible. That's what the IUPAC name is for. Is it not?

I mean, what would you say the shape of scopolamine is? "Guy falling off skateboard"? It's pretty subject to interpretation at that point. VoidHalo (talk) 23:30, 8 June 2025 (UTC)[reply]

Do you mean in the infobox? Molecular shape is relevant for intermolecular interactions. Water is a bent molecule too. It's not taking up any more space than the rest of the properties. -- Reconrabbit 15:16, 12 June 2025 (UTC)[reply]

In the section on "Oxidation" the following sentence does not seem to be illustrated properly by the subsequent reaction formula:

If an excess of oxygen is present, sulfur trioxide (SO₃) is formed, which quickly hydrates to sulfuric acid:

H₂S + 2 O₂ → H₂SO₄

I expected something like:

SO₃ + H₂O → H₂SO₄

Gil (talk) 08:55, 24 December 2025 (UTC)[reply]