Line 6, founded in 1996 and based in Agoura Hills, California, is a manufacturer of digital modelling electric guitars, amplifiers and effects processors.

The company underwent a rapid expansion in the early 2000s due to the success of their POD branded product, which imitates the sound of various classic and modern guitar amplifiers, effects pedals, amplifier cabinets and some microphones, with a good deal of accuracy. The PODxt Live product is a recent development, and extends the features of the original POD with more simulations and effects in a pedalboard package.

Line 6 currently has several other product lines in production:

Their current flagship amplifier is the Vetta II, which can model two amplifiers at once, plus multiple effects and effects chains, both pre and post amplification. The unit is software upgradable, so as new amplifier and effects models become available they can be added to the device. The Vetta I can be upgraded to a Vetta II with a software upgrade and the addition of a hardware interface. This interface provides a digital signal path for the Line 6 Variax brand of guitars. The interface takes the form of a standard RJ45 connector, which provides not only the signal path, but power to the Variax as well.

Line 6 has an active user community, and provides software that allows users to easily download and share patches or device settings. This software covers all of Line 6's existing flagship products.

Their products are used and endorsed by many professional artists.

• AxSys - The original flagship instrument amplifier from Line 6. Released in 1996 in the form of a 2x12 combo powered by 100 watts. It featured many different types of amp models that appeared original, as well as common effects such as tremolo, chorus, distortion, reverb, and delay. The amp could be controlled using an external Line 6 floorboard (either FB or FB4) or MIDI controller. In addition, the amp also shipped with inputs to control expression pedal settings.

• AX2 - An updated version of the original AxSys, was released in 1997. The new amp featured upgrades in tone and a larger amount of amp models. Owners of the original AxSys could upgrade to the new version.

• Constrictor is a stompbox from the Tonecore series of effect pedals. This pedal models compressors used in the 60s, 70s and 80s, using a switch on the pedal labeled Compressor Dynamics. 2 knobs control feature on the compressor. The Sustain knob controls how long notes are extended, and also evens out playing dynamics. The level knob controls the maximum output level of the compressor. In addition, this stompbox also features a noise gate, controlled by the corresponding knob.

• Lowdown is a new line of bass guitar amplifiers similar to the Spider II and III amps. Currently there are 4 combos available ranging from the 75 watt 1x10" Studio version up to the 300 watt 1x15" Pro version. Like the Spider III series they contain various amp models and effects.

• Pod 2.0 is an effects processor with 32 amp models and an array of effects such as delay, chorus, reverb, flanger, etc.

• Pod XT is a more advanced version of the Pod 2.0, with an LCD screen, and deeper editing of parameters. It comes in both the "kidney bean"-shaped version, the Pod XT Live version and rack-mountable Pod XT Pro version. The Pod XT Live includes a floorboard and expression pedal. Its DSP Models are expandable through the activation of additional "Packs" when the latest firmware is installed. There is a similar line of products for bass as well.

• Spider III is a line of guitar amplifiers improving on the Spider I and Spider II series. The Spider III is a solid state amp but can model various other amps and also has built in effects. Having built-in effects, the smaller combos (15 and 30 watt) are favoured by beginners, whereas the larger, more powerful units (including a high-powered stereo "head" and 4x12" cabinet) are more often used by professional musicians. In addition to the built in models and effects the Spider III series adds in artist presets allowing the user to easily emulate tones from their favourite bands.

• Toneport UX1, UX2 and KB37 are recording and modelling interfaces, giving the user access to tones available from the PODxt and Bass PODxt and more, for vocals guitar or bass, on a home computer. They also come with recording software, so the user can dial in their own sound, or use a preset tone with the software to create quality recordings that can be manipulated using the software. The KB37 is the newest addition to the series and features a 37 note keyboard in addition to all the features of the UX2.

• Variax is a line of electric guitars developed and marketed by Line 6. The first series of Variax guitars can accurately model around 25 different types of guitars, including Gibsons, Fenders, Rickenbackers and a banjo, an electric sitar, and about ten acoustic models. Another model was later introduced specializing in modeling acoustic instruments ranging from guitars to instruments from non-Western cultures. A series of modeling bass guitars followed.

• Variax Workbench is a software application that can interface a home computer with a Variax guitar to create new types of virtual guitar, allowing the user to change the body type, neck, the type, number of and position of pickups and even allows specifying alternate tunings.

• Line 6 also offers various digital effects modelling pedals and stompboxes. For example, the popular DL4 delay stompbox includes stereo delay effects, a loop sampler, and three footswitchable memory settings.

• Hawkwind
• Slipknot
• Evanescence
• Meshuggah
• The Scissor Sisters
• U2
• Dethklok
• Muse

• Line 6
• Variax guitars
• Audio interview with Line 6 founder Marcus Ryle
• Line 6 Variax History by Jim Miller