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Receptor activity is listed as antagonistic at 5-HT3 and σ receptors with IC50 of 18 μM and 145 μM, respectively. The inline citation is [5] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d7e3572d-56fe-4727-2bb4-013ccca22678. Neither the live webpage cited nor the archived version make any mention of antagonistic activity at 5-HT3 or σ receptors unless I'm mistaken. Moreover, the ligands section of the sigma receptor page lists Lamotrigine as an *agonist* of the σ receptors with two inline citations, one of which I can't access and the other of which makes no mention of activity at σ receptors at all. UriNation69420 (talk) 17:21, 26 June 2024 (UTC)[reply]

Lamotrigine is occasionally used off label for BPD

Ade RM, Patil PS, Pathade A. The Therapeutic Role of Lamotrigine in Borderline Personality Disorder: A Comprehensive Review of Outcomes, Mechanisms, and Treatment Strategies. Cureus. 2024 Aug 21;16(8):e67362. doi: 10.7759/cureus.67362. PMID: 39310624; PMCID: PMC11415144. ~2026-78963-4 (talk) 09:51, 5 February 2026 (UTC)[reply]

Thank you. I'll look at the cited text. 海盐沙冰 _{/ aka irisChronomia / Talk} 16:32, 5 February 2026 (UTC)[reply]

The amount of studies reviewed (or rather, available for review at all) seems a bit low and the conclusion seems inconclusive. I'm not sure how much of the study should be in the article... other than "people have once tried using Lamotrigine for BPD". 海盐沙冰 _{/ aka irisChronomia / Talk} 18:02, 5 February 2026 (UTC)[reply]