Leão (Portuguese for lion) may refer to:

• André Leão (born 1985), Portuguese footballer
• Anilda Leão (1923–2012), Brazilian poet, writer, actress and singer
• Aristides Leão (1914–1993), Brazilian biologist and scientist
• Augusto Pinto Duarte Maia (born 1971), Portuguese footballer known as Leão
• Chris Leão (born 1994), Brazilian TV celebrity, DJ and musical producer
• Danuza Leão (1933–2022), Brazilian model, socialite, journalist, writer and actress
• Émerson Leão (born 1949), Brazilian football player and manager
• Eriberto Leão (born 1972), Brazilian actor
• Honório Hermeto Carneiro Leão, Marquis of Paraná (1801–1856), Brazilian politician, diplomat, judge and monarchist
• Leão Lopes (born 1948), Cape Verdean director, writer, plastic artist and professor
• Mara Ferreira Leão (born 1991), Brazilian volleyball player
• Nara Leão (1942–1989), Brazilian singer and actress
• Rafael Leão (born 1999), Portuguese footballer
• Ricardo Leão (born 1975), Portuguese politician
• Rodrigo Leão (born 1964), Portuguese musician and songwriter
• Rodrigo Leão (volleyball) (born 1996), Brazilian indoor volleyball player

• "Leão" (Marília Mendonça song), a song by Xamã and Marília Mendonça
• Leão River, a river in Santa Catarina, Brazil
• Leão River (Rio Grande do Sul), a river in Rio Grande do Sul, Brazil
• Matte Leão, a Brazilian infusion and tea brand