John E. Smith may refer to:

• John E. Smith (general), a Swiss immigrant to the United States who served as a Union general during the American Civil War
• John E. Smith (New York politician) (1843–1907), American politician
• John E. Smith, Director of U.S. Treasury Office of Foreign Assets Control
• John Eldon Smith (1930–1983), American murderer
• John Eldrid Smith, South African judge
• John Edwin Smith, American philosopher
• J. E. Smith (c. 1862/1863–1912), English trade union leader

• John Smith (disambiguation)
• Johnny Smith (disambiguation)