Gillette is a surname. Notable people with the surname include:

• Anita Gillette (born 1936), American actress and game-show panelist
• Arthur Gillette (1869–1921), American pediatric orthopedic surgeon
• Chester Gillette (1883–1908), American murderer
• Clarence Preston Gillette (1859–1941), American entomologist
• David Gillette (1946–2025), American paleontologist
• Douglas W. Gillette (1918–1942), American naval officer
• Elizabeth V. Gillette (1874–1965), New York physician, assemblywoman 1920
• Frank Gillette (born 1941), American video and installation artist
• Frank E. Gillette (1848–1923), American politician and judge, Associate Justice of the Oklahoma Territory Supreme Court (1902-1907)
• Guy Gillette (1879–1973), American politician from Iowa
• Jim Gillette (born 1967), American singer
• King C. Gillette (1855–1932), American businessman and founder of the Gillette Safety Razor Company
• Lee Gillette (1912–1981), American record producer and A&R director
• Mic Gillette (1951–2016), American brass player, member of the R&B band Tower of Power
• Paul Gillette (1938–1996), author and wine expert
• Sandra Gillette (born 1974), American singer and rapper known as Gillette (singer)
• William Gillette (1853–1937), American actor famous for his stage version of Sherlock Holmes

• Ray Gillette, a character in American animated sitcom Archer

• Gillette (disambiguation)
• Gillett (surname)