The surname Alphonse or Alfonse may refer to:

• Alexandre Alphonse (born 1982), French-born Guadeloupean footballer
• Eloi Maxime Alphonse (born 1957), Malagasy diplomat and politician
• Gerard A. Alphonse, electrical engineer, physicist and research scientist
• Jean Alfonse (c. 1484–1544 or 1549), Portuguese navigator, explorer and corsair
• Jefferson Alphonse (born 2003), Canadian soccer player
• Jules Alfonse (1911–2000), American football player
• Kódjo Kassé Alphonse (born 1993), Ivorian footballer
• Lylah M. Alphonse (born 1972), American journalist
• Mickaël Alphonse (born 1989), French footballer
• Nadine Alphonse, Canadian volleyball player, member of Canada women's national volleyball team 2008–2011
• S. Peter Alphonse, Indian politician

• All pages with titles containing Alphonse
• Alphonse (given name)
• Alfonso (disambiguation)