Loser or Losers may refer to:

• A person, or people, who experience failure
• The unsuccessful social class in winner and loser culture

• Loser (1996 film), an American drama film
• Loser (2000 film), an American comedy film
• Losers (film), a 2015 Bulgarian comedy-drama film
• The Losers (2010 film), an American action film

• Loser (TV series), a 2020 Indian drama television series
• "Loser" (Grounded for Life), a 2001 television sitcom episode
• Losers (TV series), a 2019 American documentary television series
• Loser, a character from the fourth season of Battle for Dream Island, an animated web series
• L.O.S.E.R.S., fictional characters featured in The Fairly OddParents

• Loser (novel), a 2002 novel by Jerry Spinelli
• Losers (comics), two comic book series published by DC Comics
  • The Losers (Vertigo), the Vertigo "modernization" of the classic comic
• The Loser, a 1983 novel by Thomas Bernhard

• Loser (band), an American rock band
• Losers (band), a British rock band

• Losers (album), a 1990 album by Sentridoh

• "Loser" (Beck song), a 1993 single
• "Loser" (BigBang song), a 2015 single
• "Loser" (3 Doors Down song), a song from the album The Better Life
• "Loser" (Tame Impala song), a song from the album Deadbeat
• "Loser", a song by Jerry Garcia from the album Garcia
• "Loser / Number Nine", a 2016 single by Kenshi Yonezu
• "Loser", a song by Alma from the album Have U Seen Her?
• "Loser", a song by Ayreon from the album The Human Equation
• "Loser", a song by Charlie Puth from the album Charlie
• "Loser", a song by Jim Martin from the album Milk and Blood
• "Loser", a song by Limp Bizkit from the album Gold Cobra
• "Loser", a song by MC Cheung from the album Have A Good Time
• "Losers", a song by the Belle Brigade from the album The Belle Brigade
• "Losers", a song by the Cardigans from the album First Band on the Moon
• "Losers" (Post Malone song), a song from the album F-1 Trillion
• "Losers", a song by The Weeknd from the album Beauty Behind the Madness

• In contract bridge, a card which will never win a trick
• Loser (hand gesture), a hand gesture made by extending the thumb and index fingers, leaving the other fingers closed to create the letter L, interpreted as "loser", and generally given as a demeaning sign
• Loser (mountain), a mountain in Ausseerland, Styria, Austria
• Loser, one of the three peaks in the Leuser Range
• Loser.com, a domain name and URL redirect that has existed since 1995

• Lose (disambiguation)
• The Losers (disambiguation)
• Lovable loser, a character archetype
• Losar, a new year festival in Tibetan Buddhism