Temarotene is a synthetic arotinoid compound with the molecular formula C23H28.[2][3] The compound is an orally active drug known for its immunosuppressive and immunostimulatory activities. Temarotene was also studied as a chemopreventive agent.

Synthesis

Synthesis of arotinoid acid and temarotene starts with mixed (Z)-1,2-bis(organylchalcogene)-1-alkene as a precursor.[4]

Uses

Temarotene functions as an orally administered immunomodulator, exhibiting both immunosuppressive and immunostimulatory properties. Studies demonstrate its ability to regulate ornithine decarboxylase (ODC) gene expression in vitro, a mechanism linked to its effects on cellular differentiation and immune response. Temarotene is also used in the study of lichen planus.[5]

References

  1. ↑ Wolverton, Stephen E. (2001). Comprehensive Dermatologic Drug Therapy. Saunders. p. 302. ISBN 978-0-7216-7728-6. Retrieved 13 April 2025.
  2. ↑ Hong, Waun Ki; Lotan, Reuben (24 July 2020). Retinoids in Oncology. CRC Press. p. 92. ISBN 978-1-000-14822-0. Retrieved 13 April 2025.
  3. ↑ "NCATS Inxight Drugs — TEMAROTENE". drugs.ncats.io. Retrieved 13 April 2025.
  4. ↑ Guerrero, Palimécio G.; de Oliveira, Paulo R.; Baroni, Adriano C. M.; Marques, Francisco A.; Labes, Ricardo; Hurtado, Gabriela R.; Dabdoub, Miguel J. (26 September 2012). "Synthesis of arotinoid acid and temarotene using mixed (Z)-1,2-bis(organylchalcogene)-1-alkene as precursor". Tetrahedron Letters. 53 (39): 5302–5305. doi:10.1016/j.tetlet.2012.07.092. hdl:11449/194747. ISSN 0040-4039.
  5. ↑ "Temarotene | TargetMol". targetmol.com. Retrieved 13 April 2025.
allikas: https://en.wikipedia.org/wiki/Temarotene