GS (IUPAC name: Cyclopentyl methylphosphonofluoridate), also known as G-agent S candidate No. 3 or EA-1246 (Edgewood Arsenal cryptonym), is an organophosphate nerve agent, part of a series of nerve agents "G-series".[1] It is a potent acetylcholinesterase inhibitor with properties similar to other nerve agents. GS is structurally a derivative of the nerve agent sarin, being closely structurally related to GP. It is a derivative of its acyclic equivalent, 3-pentanyl methylphosphonofluoridate.[2]
GS rapidly ages the acetylcholinesterase, exhibiting a rate approximately half that of soman and 60 times faster than its larger GF counterpart.[3][4] GS was the third candidate in a series of 6 other organophosphonates, in which the vast majority are cycloalkyl/alkyl methylphosphonofluoridates, with the exception of GS-7, a derivative of the pesticide monitor.[3]
References
- ↑ Samuel, John B.; Penski, Elwin C.; Callahan, John J.. Physical Properties of Standard Agents, Candidate Agents, and Related Compounds at Several Temperatures - Special publication Aug 1970-Sep 1982. ARMY ARMAMENT RESEARCH AND DEVELOPMENT COMMAND ABERDEEN PROVING GROUND MD CHEMICAL SYSTEMS LAB. 1983 May 01
- ↑ "Investigation of chemical warfare installations in the Munsterlager area, including Raubkammer - Digital Collections - National Library of Medicine". collections.nlm.nih.gov. Retrieved 2026-02-16.
- 1 2 Mager, Peter P. (1984). Multidimensional pharmacochemistry: design of safer drugs. Medicinal chemistry. Orlando: Academic Press. ISBN 978-0-12-465020-6.
- ↑ De Jong, L. P. A.; Wolring, G. Z. (1978-01-01). "Reactivation and aging of cyclopentyl methylphosphonylated acetylcholinesterase in the presence of some 1-alkyl-2-hydroxyiminomethyl-pyridinium salts". Biochemical Pharmacology. 27 (24): 2911–2917. doi:10.1016/0006-2952(78)90208-3. ISSN 0006-2952. PMID 736984.