MW073 is a serotonin 5-HT2B receptor antagonist which is used in scientific research.[1][2][3][4][5] It is a highly selective antagonist of the serotonin 5-HT2B receptor.[3][2] The drug is orally active in animals and is said to have a favorable drug-like profile.[3][2] It produces antiaggressive effects without causing sedation or altering locomotor activity or anxiety in an animal model of Alzheimer's disease.[3][2] Similarly, it produces neuroprotective, neurorestorative, and pro-cognitive-like effects in such models.[3][2][5] MW073 was first described in the scientific literature by 2024.[4][2][3][5] There is interest in MW073 for the potential treatment of Alzheimer's disease and other conditions.[3][2]

See also

References

  1. ↑ "Delving into the Latest Updates on MW073 with Synapse". Synapse. 9 May 2026. Retrieved 9 June 2026.
  2. 1 2 3 4 5 6 7 Roy SM, Acquarone E, Argyrousi EK, Zhang H, Staniszewski A, Inoue A, et al. (2025). "Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction". Alzheimer's & Dementia. 11 (1) e70073. New York, N. Y. doi:10.1002/trc2.70073. PMC 11947739. PMID 40151398.
  3. 1 2 3 4 5 6 7 Acquarone E, Roy SM, Staniszewski A, Watterson DM, Arancio O (February 2026). "The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer's Disease Mouse Model". Cells. 15 (3). doi:10.3390/cells15030273. PMC 12896383. PMID 41677635.
  4. 1 2 Acquarone E, Argyrousi EK, Arancio O, Watterson DM, Roy SM (2024). "The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction". Journal of Alzheimer's Disease. 98 (4): 1349–1360. doi:10.3233/JAD-240063. PMC 11091653. PMID 38578894.
  5. 1 2 3 Roy S, Acquarone E, Ziarek JJ, Ottavio A, Watterson DM (2026). "MW073 Treatment Attenuates Synaptic Dysfunction, Cognition-Related Behavior Deficits, and Aggression in Alzheimer's Disease Models (Abstract ID: 273213)". The Journal of Pharmacology and Experimental Therapeutics. 393 (5) 104835. doi:10.1016/j.jpet.2026.104835.
allikas: https://en.wikipedia.org/wiki/MW073