U.S. Route 82 (US 82) is a section of a west-east highway that travels through Mississippi. It starts at the Arkansas state line at Refuge and ends at the Alabama state line east of Columbus.

As are most other US numbered highways in the state, this entire section of US 82 is defined in Mississippi Code Annotated § 65-3-3.^[3]

Through the entire state, the highway is four-laned with interchanges at major junctions. After crossing the Mississippi River from Arkansas via the four-laned, cable-stayed Greenville Bridge, the road briefly travels northeast toward central Greenville, then turns east toward Leland, where it intersects US 61, as US 278 breaks it concurrency and goes on to follow US 61 north. US 82 continues eastward, intersecting US 49W in Indianola, US 49E in Greenwood, I-55 and US 51 in Winona, and passing through Starkville.

From Starkville east through Columbus up until the Alabama state line, US 82 is built to freeway standards. It forms a brief concurrency with US 45 in Columbus, as both highways cross the Tennessee-Tombigbee Waterway together via an unnamed bridge. As US 45 heads north, US 82 continues to wind its way around the city, finally crossing into Alabama almost immediately after an interchange with Lee Stokes Road.

US 82 was first requested by MDOT in part as a route that extended from Texarkana, Arkansas to Columbus. Their request was approved on July 1, 1931 after a similar request was made from AHTD processed a similar request. Eventually, in June 1934, an expansion to Tuscaloosa was approved and completed in the same year. The length of US 82 began shortening sometime just before 1939, mainly within cities. The length of the highway in the state was shortened even further by 1942.^[2]

Construction is now underway on a U.S. 82 bypass around Greenville. The new road will commence at the Greenville Bridge and terminate at the current US 82 near Leland, creating a half-loop freeway around South Greenville. Cloverleaf interchanges are presently being built at the freeway's junctions with MS 454 and MS 1. The bypass is scheduled for completion in fall 2025.^[4][5]

County	Location	mi	km	Destinations	Notes
Mississippi River		0.0	0.0	US 82 west / US 278 west continue via the Greenville Bridge into Arkansas
Washington	Refuge	1.1	1.8	MS 454 east – Wayside	Future bypass route; western terminus of MS 454
	Greenville	9.7	15.6	MS 1 / Great River Road (Martin Luther King Jr Boulevard) – Metcalfe, Avon
	Leland	17.4	28.0	Broad Street	Former US 61 north; future bypass route
		18.9– 19.5	30.4– 31.4	US 61 / US 278 – Rolling Fork, Cleveland	Interchange; eastern end of US 278 concurrency
Sunflower	Indianola	33.0	53.1	MS 448 west – Shaw	Eastern terminus of MS 448
		33.7	54.2	US 49W (Martin Luther King Drive) – Yazoo City, Tutwiler
	Moorhead	40.9	65.8	MS 3 – Sunflower, Inverness
Leflore	Itta Bena	53.4	85.9	MS 7 south (Schley Street) – Belzoni	Western end of MS 7 concurrency
	Greenwood	57.9	93.2	US 49E north – Tutwiler	Western end of US 49E concurrency
		62.2– 62.6	100.1– 100.7	US 49E south – Yazoo City Main Street (MS 743 north) - Downtown	Interchange; eastern end of US 49E concurrency; southern terminus of unsigned MS 743
		63.6– 63.7	102.4– 102.5	MS 744 west	Eastern terminus of MS 744; no left turn eastbound
		63.8	102.7	MS 430 east – Blackhawk, Vaiden	Western terminus of MS 430
		64.1	103.2	MS 7 north – Grenada	Eastern end of MS 7 concurrency
Carroll	​	77.8	125.2	MS 17 / MS 35 north (Lexington Street) – Carrollton, North Carrollton, Holcomb, Lexington	Western end of MS 35 concurrency
	​	79.4	127.8	MS 35 south – Vaiden, Kosciusko	Eastern end of MS 35 concurrency
Montgomery	Winona	86.8	139.7	I-55 – Jackson, Grenada	I-55 exit 185
		87.6	141.0	MS 182 east (Middleton Road) – Downtown	Western terminus of Winona section of MS 182
		88.9	143.1	US 51 (N Applegate Street) – Winona, Duck Hill	Interchange
	Kilmichael	98.3	158.2	MS 182 east (N Rutherford Drive) – Kilmichael	Western terminus of Kilmichael section of MS 182
		100.6	161.9	MS 182 (S Rutherford Drive) to MS 413 – Kilmichael, French Camp	Eastern terminus of Kilmichael section of MS 182
Webster	​	116.6	187.6	MS 182 east (W Roane Avenue) – Eupora	Western terminus of Europa section of MS 182
	Eupora	119.5	192.3	MS 9 – Ackerman, Europa	Interchange
	​	122.0	196.3	MS 182 west (E Roane Avenue) – Eupora	Eastern terminus of Europa section of MS 182
	​	126.7	203.9	Natchez Trace Parkway	Interchange
	Mathiston	127.8	205.7	MS 15 south / MS 403 north (Horton Street) – Ackerman, Louisville	Western end of MS 15 concurrency; southern terminus of MS 403
		128.7	207.1	MS 15 north – Maben, Pontotoc	Interchange; Eastern end of MS 15 concurrency
Oktibbeha	​	137.9	221.9	MS 182 east – Adaton, Starkville	Western terminus of Starkville section of MS 182
	Starkville	144.6– 145.3	232.7– 233.8	MS 25 south – Louisville	Interchange; west end of freeway; western end of MS 25 concurrency
		145.6	234.3	MS 389 – Pheba, Starkville
		147.7– 148.2	237.7– 238.5	MS 12 – Starkville, Mississippi State University	Western end of MS 12 concurrency
	Clayton Village	149.5– 150.0	240.6– 241.4	MS 182 – Starkville, Clayton Village
	​	153.5	247.0	Hickory Grove Road
Lowndes	​	156.3	251.5	US 45 Alt. / MS 25 – West Point, Brooksville	Eastern end of MS 25 concurrency
	​	160.5	258.3	MS 791 south	Access to Golden Triangle Regional Airport; northern terminus of MS 791
	​	166.2	267.5	US 45 south – Macon, Meridian	Western end of US 45 concurrency
	Bridge over the Tennessee-Tombigbee Waterway
	Columbus	169.4	272.6	MS 182 east (Main Street) – Columbus	Western terminus of Columbus section of MS 182
		170.0	273.6	US 45 north / MS 50 west / MS 69 south (N 5th Street) – West Point, Aberdeen, Amory	Eastern end of US 45 concurrency; Western end of MS 50 concurrency; Northern terminus of MS 69
		170.6	274.6	North 18th Avenue
		171.7	276.3	Military Road
		173.9	279.9	MS 12 east / MS 50 east (Tuscaloosa Road)	Eastern end of MS 12 concurrency; Eastern end of MS 50 concurrency
	​	178.9– 179.3	287.9– 288.6	Lee Stokes Road
Alabama state line		180.0	289.7	US 82 east continues into Alabama East end of freeway SR 6 east begins
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Unopened

• Media related to U.S. Route 82 in Mississippi (state) at Wikimedia Commons

U.S. Route 82
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