Luca Pellegrini (born 24 March 1963) is an Italian former professional footballer who played as a defender.

Pellegrini was born in Varese. He played for 11 seasons (262 games, 3 goals) in the Serie A for U.C. Sampdoria, Hellas Verona F.C. and Torino F.C.

Pellegrini represented Italy at the 1988 Summer Olympics (a swimmer with the same name also represented Italy at those Olympics).

His younger brothers Davide Pellegrini and Stefano Pellegrini also played football professionally. To distinguish them, Luca was referred to as Pellegrini I, Davide as Pellegrini II and Stefano as Pellegrini III.

Sampdoria

• Serie A: 1990–91
• Coppa Italia: 1984–85, 1987–88, 1988–89
• UEFA Cup Winners' Cup: 1989–90