Rafael Nadal defeated Cameron Norrie in the final, 6–4, 6–4 to win the singles title at the 2022 Mexican Open. Nadal did not drop a set during a tournament for a record-extending 30th time.^[1] It was his fourth Acapulco title and 91st career singles title overall.^[2]

Alexander Zverev was the defending champion,^[3] but he was defaulted from the tournament prior to his second-round singles match after he showed unsportsmanlike conduct at the conclusion of his first-round doubles match, repeatedly hitting the umpire’s chair with his racquet and using obscene language.^[4]

Zverev and Daniil Medvedev were in contention to claim the world No. 1 singles ranking.^[5] After Novak Djokovic lost in the quarterfinals in Dubai, Medvedev clinched the top ranking for the first time, making him the 27th player to hold the position.^[6] Medvedev also became the first player outside of the Big Four to hold the world number 1 ranking since Andy Roddick in February 2004, ending the quartet's 943-week streak with the top position.^[7]

For the first time since the 2013 China Open, four of the top five ranked players competed at the same ATP 500 tournament.^[8]

The first-round match between Zverev and Jenson Brooksby had the latest-ever finish in an ATP Tour match when it ended at 4:55 a.m. local time, passing the previous record of 4:34 a.m. local time set by Lleyton Hewitt and Marcos Baghdatis at the 2008 Australian Open. At three hours and twenty-two minutes, it was also the longest match ever played at the Mexican Open.^[8]

	Semifinals							Final
	1	Daniil Medvedev	3	3
	4	Rafael Nadal	6	6
								4	Rafael Nadal	6	6
								6	Cameron Norrie	4	4
	3	Stefanos Tsitsipas	4	4
	6	Cameron Norrie	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	D Medvedev	6	6
		B Paire	3	4				1	D Medvedev	6	6
	WC	A Hernández	0	1				PR	P Andújar	1	2
	PR	P Andújar	6	6											1	D Medvedev	6	6
	WC	F López	6	0	4										Q	Y Nishioka	2	3
	Q	Y Nishioka	2	6	6			Q	Y Nishioka	3	6	6
		A Mannarino	3	3				7	T Fritz	6	4	2
	7	T Fritz	6	6																		1	D Medvedev	3	3
	4	R Nadal	6	6																		4	R Nadal	6	6
	LL	D Kudla	3	2				4	R Nadal	6	6
		G Dimitrov	68	7	3			LL	S Kozlov	0	3
	LL	S Kozlov	710	5	6										4	R Nadal	6	77
		D Lajović	6	4	7											T Paul	0	65
		S Korda	4	6	5				D Lajović	66	6	5
		T Paul	4	5					T Paul	78	2	7
	5	M Berrettini	6	1r

	First round							Second round							Quarterfinals							Semifinals
	8	P Carreño Busta	6	6
	Q	O Otte	2	4				8	P Carreño Busta	79	4	64
	SE	J Millman	63	0r					M Giron	67	6	77
		M Giron	77	2												M Giron	3	4
	Q	JJ Wolf	3	79	6										3	S Tsitsipas	6	6
		L Sonego	6	67	2			Q	JJ Wolf	1	0
		L Đere	67	64				3	S Tsitsipas	6	6
	3	S Tsitsipas	79	77																		3	S Tsitsipas	4	4
	6	C Norrie	77	6																		6	C Norrie	6	6
	Q	D Altmaier	65	2				6	C Norrie	62	6	6
	WC	F Verdasco	5	77	63				J Isner	77	3	4
		J Isner	7	64	77										6	C Norrie	6	6
		B Nakashima	4	4											LL	P Gojowczyk	1	0
	LL	P Gojowczyk	6	6				LL	P Gojowczyk	0
		J Brooksby	6	610	2			2	A Zverev	0d
	2	A Zverev	3	712	6

	First round							Qualifying competition
	1	Daniel Altmaier	6	3	6
		Ernesto Escobedo	2	6	1
								1	Daniel Altmaier	4	6	6
								6	Denis Kudla	6	4	2
	WC	Rodrigo Pacheco Méndez	6	4	1
	6	Denis Kudla	4	6	6

	First round							Qualifying competition
	2	Oscar Otte	6	6
		Emilio Gómez	3	1
								2	Oscar Otte	6	0	77
								Alt	Stefan Kozlov	1	6	62
	Alt	Stefan Kozlov	6	6
	5	Steve Johnson	4	3

	First round							Qualifying competition
	3	Kevin Anderson	6	78
	WC	Nicolás Mejía	3	66
								3	Kevin Anderson	77	4	3
								PR	J. J. Wolf	63	6	6
	PR	J. J. Wolf	6	6
	8	Andreas Seppi	4	2

	First round							Qualifying competition
	4	Peter Gojowczyk	6	6
	WC	Gerardo López Villaseñor	1	1
								4	Peter Gojowczyk	3	2
								7	Yoshihito Nishioka	6	6
	PR	Cedrik-Marcel Stebe	6	3	4
	7	Yoshihito Nishioka	1	6	6

• Main draw
• Qualifying draw