St. Andrew's Cross may refer to:
- Saltire, a heraldic symbol in the form of a diagonal cross
- St. Andrew's cross (philately), a saltire that occurs on some philatelic items
- Saint Andrew's Cross (BDSM), a common piece of equipment in BDSM dungeons
- St Andrew's Cross, Glasgow, a road junction in Glasgow, Scotland
- Hypericum hypericoides, or St. Andrew's cross, a species of flowering plant
- Argiope (spider), or St. Andrew's cross spider, a genus of spiders