Muscle Shoals is a city in Alabama.
Muscle Shoals also may refer to:
- Muscle Shoals Sound Studio, an American recording studio in Sheffield, Alabama
- Muscle Shoals (film), a 2013 documentary about the studio
- Muscle Shoals Rhythm Section, a group of American session musicians based in Muscle Shoals, Alabama
- Leo "Muscle" Shoals (1916–1999), baseball player