The following highways are numbered 422:

• Manitoba Provincial Road 422
• Newfoundland and Labrador Route 422

• Route 422 (Japan)

• Interstate 422 (future)
• U.S. Route 422
• Georgia State Route 422 (unsigned designation for Georgia State Route 10 Loop)
• Louisiana Highway 422
• Maryland Route 422
• New York State Route 422 (former)
• Oregon Route 422
  • Oregon Route 422S
• Puerto Rico Highway 422
• Tennessee State Route 422
• Texas State Highway Spur 422

• Special routes of U.S. Route 422