John Smythe may refer to:

• John Smythe (High Sheriff of Kent), MP for Aylesbury and Hythe
• John Smythe (MP for Buckingham) (c.1599–1640), MP for Buckingham, 1626
• John Smythe (MP for Richmond) (died 1599/1600), MP for Richmond

• John Smythe (field hockey) (born 1989), Canadian field hockey player
• John Smythe (playwright), involved with the establishment of Nindethana Theatre in Melbourne, Australia, in 1971
• John Smythe (screenwriter) of The Search for Animal Chin (1987)
• John H. Smythe (1844–1908), United States ambassador to Liberia
• John Henry Clavell Smythe (1915–1996), Sierra Leone Creole, Royal Air Force member and lawyer
• Sir John Smythe (soldier) (1531-1607), English soldier, diplomat and military writer.
• Sir John Smythe, 3rd Baronet (died 1737) of the Smythe baronets
• Sir John Smythe, 8th Baronet (1827–1919) of the Smythe baronets

• John Smyth (disambiguation)
• John Smith (disambiguation)
• All pages with titles containing John Smythe